'Master regulator' of obesity? Distant IRX3 gene appears to interact with obesity-related FTO gene mutations

The study appears online March 12 in Nature.

"Our data strongly suggest that IRX3 controls body mass and regulates body composition," said senior study author Marcelo Nobrega, PhD, associate professor of human genetics at the University of Chicago. "Any association between FTO and obesity appears due to the influence of IRX3."

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